If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). I mean, he really, truly has a heart of gold, Char told me. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. If you cant get a prescription for COVID, then perhaps you have OCD? I bumped up the reward to $1M. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Summary of key evidence. So far, doctors have failed to share his sense of urgency. Im sorry to sound so cynical. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. I think so. Its motivated out of his sense of keeping people safe and advancing health care.. People are dying. A very short op-ed arguing for using fluvoxamine against COVID. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Fluvoxamine was reportedly added to just 2 practice guidelines (. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. Medicine isnt about saving lives anymore. @stkirsch. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Get your prescription in advance of getting COVID. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. In some cases, youd want to taper down the dosage. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. MisinformationKills. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. Note that some of these articles are inaccurate. So you can address your OCD and if you get COVID, youll can up the dose. The babys brain was split in half, and it was just covered with blood. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. 12:45 AM . skirsch.io Steve Kirsch Home page. So it was both obvious and convincing the difference between the groups to the workers and the track management. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. I've collected fluvoxamine evidence here for convenient access. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. There were no studies reported out so far where fluvoxamine made things worse or neutral. Their willingness to lie did. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. Hes very convincing. Zero. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. 1. Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. Fluoxetine is just as effective. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. I couldn't agree more. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. MD, MPH; Steven C. Marcus, PhD. Quick Summary . Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. The data is there in plain sight for anyone to see today. The medical community did nothing (with a few exceptions like Dr. Seftel). CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Part of TV News Archive. Now weve lost the high ground, Morris told me. 1991-1992 to 7.1% in 2001-2002. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. 19 In addition, several . It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. But fear of trying something new prevents any doctor from giving this drug a try. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. Has it really been 25 years, a whole quarter of a century? Another is to identify an asteroid that is going to hit the planet.. So why would we wait when lives are being lost? For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. Its all about NIH saying it is OK. . Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. has tons of info on fluvoxamine with all the links. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Steve Kirsch is a Silicon Valley philanthropist. He may not be a good scientist, but hes smart, says WVUs Feinberg. Stopping the meds will return you to your normal self. The track management was so impressed, they asked for prescriptions. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. No more. So you can address your OCD and if you get COVID, youll can up the dose. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . See the repository above. So there were too few events in the placebo group and they werent recruiting fast enough. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). Im not going to make the same mistake again.. We should not wait for the Phase 3 RCT. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. That receptor also helps regulate the body's . The rest of the board soon followed. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Mouse Systems is not a household word, he told the journalist. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). Timing is everything with respect to outcomes. He has a BS/MS in Electrical Engineering and Computer Science from MIT. If you continue to get this message, This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). He started 7 high tech companies, two with billion dollar market caps. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Steve Kirsch. Enter the email address you signed up with and we'll email you a reset link. more time. Silence from the medical community. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. FDA official fluvoxamine rejection. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. Saving the world has been a theme of Kirschs life for years. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. (article I did after the TOGETHER trial). I took it myself at that dosage and noticed zero side effects. Talking to Kirsch is an exhausting experience. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Reason is the hospital gets release from liability if they follow NIH guidelines. Personal life. Please. His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. Doing something is better than nothing. It could do nothing. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. The race to find covid-19 drug treatments that actually work, The antimalarial drug Trump took for covid might actually be dangerous. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. The 5 observational studies is icing on the cake. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. You cannot get any better than that. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. As noted before, the repository has a link to the 1 hour serotonin lecture. The drug was FDA-approved more than 65 years ago. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Comparison with molnupiravir. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: The sooner you start, the better the outcomes. Theyre finding alternative leaders to follow, Morris said. The anecdotal data of 100% success rates is further icing on the cake. So take the lowest likely effect size * 60% success rate and you are looking at an expected 45% reduction in death which is clearly better than a 0% reduction. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. Reason is the hospital gets release from liability if they follow NIH guidelines. We are ignoring the advice of the KOL group and doing nothing. I believe they made the right decision and we should be rushing to follow their advice. including the very promising Fluvoxamine. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. Don't underestimate the virus. Jan 17. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. . Have the drug on hand. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. My crime? CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . Links to evidence about fluvoxamine including the public data repository. This document is a collection of evidence that highlights the glaring errors in our pandemic response. He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. The CDC has advised everyone to wear a mask. Drug interactions should be checked for. He's founded 7 companies, 2 with billion dollar valuations. Author Affiliations Article Information. The track management was so impressed, they asked for prescriptions. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. I couldnt tell I was on the drug. February 17, 2021. . In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. . Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. Zero. Steve put in $1MM of his own money and . Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Keeping this drug off the NIH Guidelines does nothing to reduce the death rate. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Compulsive fiddling with your mask? Who knows, Morris replied. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Once the Phase 2 result came out, it should have been embraced by doctors. Telling the truth, he tweeted. . May 16, 2022. If you take fluvoxamine, please avoid caffeine while on the drug. I fixed the link to the fluvoxamine article. Stopping the meds will return you to your normal self.