Our analysis . Omicron Is Not More Severe for Children, Despite Rising But those countries have high vaccination rates, and there, too, Omicron has spread most quickly among younger adults. RESP-NET: COVID-19 Associated Hospitalization Rates among Adults Ages 65 Years and Older CDC's Respiratory Virus Hospitalization Surveillance Network (RESP-NET) shows that overall weekly rates of COVID-19-associated hospitalizations have declined for all age groups from a peak in December 2022. Thank you for taking the time to confirm your preferences. Among children 12 to 17, the . Pediatrics. During the Omicron dominant period, maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive by 43% (95% CI: 4, 69) during the first 2 months of life, 36% (95% CI:11, 55) during the first 4 months of life, and 41% (95% CI: 25, 53) during the first 6 months of life (Supplemental Table2). Libby Reeg reports grants from the Michigan Department of Health and Human Services during the conduct of the study. of pages found at these sites. Age-adjusted rates were calculated by dividing the number of hospitalized COVID-19 patients by population estimates for race/ethnicity, and vaccination status in the catchment area. While Omicron caused a big spike in COVID-19 cases, vaccinated people continued to be less likely to be hospitalized than the unvaccinated. Maryland did not contribute data after December 4, 2021, but did contribute data for previous weeks. 41, e81e86 (2022). The population of unvaccinated adults is determined by subtracting the number of adults who received any dose of vaccine, as previously defined, from the population. 387, 109119 (2022). Data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to compare COVID-19associated hospitalization rates among adults aged 18 years during B.1.617.2 (Delta; July 1December 18, 2021) and Omicron (December 19, 2021January 31, 2022) variant predominance, overall and by race/ethnicity and vaccination status. Article In our primary analysis, we implemented a cohort study design where we used Cox proportional hazards models that allow for time-varying covariates to estimate the SARS-CoV-2 infection hazard ratio (HR) in infants of mothers vaccinated with at least 2 doses of mRNA COVID-19 vaccines during pregnancy and 1 dose only versus mothers who were unvaccinated during pregnancy. Buchan, S. A. et al. We conducted a descriptive analysis of the study population and calculated crude rates of SARS-CoV-2 infection and hospitalization by maternal vaccination status. SGN, HHW, NA, WH, MK, PB, AZ, JLB, MC, NAA, KH, RH, AC, GD, and ST curated the data. Delahoy MJ, Whitaker M, OHalloran A, et al. J. Obstet. Am. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020. All authors (O.Z., B.F., N.P.K., T.R., M.G., E.L., P.R., K.G., S.O., and E.L.) critically reviewed the manuscript and decided to proceed with publication. Models in this analysis were adjusted for the same covariates included in the primary analysis. 384, 21872201 (2021). Introduction: A rapid increase in COVID-19 cases due to the spread of the Delta and Omicron variants in vaccinated populations has raised concerns about the hospitalization risk associated with, and the effectiveness of, COVID-19 vaccines. There were only one hospitalized case among the children of vaccinated mothers and nine hospitalized cases among the children of unvaccinated mothers (Table1). Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. B., Lewis. Data about boosters was only available for those over 50. Google Scholar. According to the Ontario Science Table's online dashboard, the hospital occupancy rate for the unvaccinated was 611 per million unvaccinated people in the province's population as of Jan. 7,. Hospitalization rates were 10.5 times higher in the unvaccinated and 2.5 times higher in vaccinated patients with no booster than in booster recipients. Children born at Kaiser Permanente Northern California from December 15, 2020, through May 31, 2022. Kharbanda, E. O. et al. https://medrxiv.org/cgi/content/short/2021.08.27.21262356v1. Weekly rates among unvaccinated adults and adults who received a primary COVID-19 vaccination series with a booster or additional dose peaked at 149.8 (January 8, 2022) and 11.7 (January 22, 2022), respectively. Mountain lions, a bobcat, red foxes, black bears, and skunks represent the latest avian flu cases in mammals. Sign up for notifications from Insider! and/or the original MMWR paper copy for printable versions of official text, figures, and tables. Accessed March 10, 2022. The average death rate among Americans over age 65 who contract the flu has ranged between 1 in 75 and 1 in 160 in recent years, according to the C.D.C. The second study, led by Office for National Statistics researchers in Wales, involved death rates and risk factors in adults in England who had received an mRNA booster at least 14 days before Dec 31, 2021. COVID-19 vaccine surveillance report: week 6. Structural changes in the brain may explain the persistent fatigue and neuropsychiatric complications tied to long COVID. supervised chart reviews. No other potential conflicts of interest were disclosed. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. *** An additional 172 (3.4%, 95% CI = 2.7%4.2%) adults were partially vaccinated, 69 (0.9%, 95% CI=0.61.2) received a primary vaccination series <14 days before receiving a positive SARS-CoV-2 test result, and 186 (4.1%) had unknown vaccination status; these groups are not further described in this analysis. 20, 15225 (2016). Access your favorite topics in a personalized feed while you're on the go. Iowa does not provide data on vaccination status. https://doi.org/10.1016/j.jpeds.2022.09.059 (2022). of Omicron-infected patients with a high rate of vaccination in China. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. On the bias of estimates of influenza vaccine effectiveness from test-negative studies. The final study population included 30311 (48.8%) infants who were KPNC members at least 2 months after birth. MMWR Morb Mortal Wkly Rep 2022;71:14652. The results were published yesterday in JAMA Network Open. Slider with three articles shown per slide. COVID-19 incidence and death rates among unvaccinated and fully vaccinated adults with and without booster doses during periods of Delta and Omicron variant emergence25 U.S. Jurisdictions, April 4December 25, 2021. The funders played no direct role in the study. Monthly incidence is based on SARS-CoV-2 positive test result date or, if not known, hospital admission date. ; COVID-NET Surveillance Team. All authors reviewed the manuscript. The increase in transmissibility of the Omicron variant might have amplified these risks for hospitalization, resulting in increased hospitalization rates among Black adults compared with White adults, irrespective of vaccination status. **** ICU admission and IMV are not mutually exclusive categories, and patients could have received both. Risk of hospitalisation associated with infection with SARS-CoV-2 lineage B.1.1.7 in Denmark: an observational cohort study. COVID-19associated signs and symptoms included respiratory symptoms (congestion or runny nose, cough, hemoptysis or bloody sputum, shortness of breath or respiratory distress, sore throat, upper respiratory infection, influenza-like illness, and wheezing) and non-respiratory symptoms (abdominal pain, altered mental status or confusion, anosmia or decreased smell, chest pain, conjunctivitis, diarrhea, dysgeusia or decreased taste, fatigue, fever or chills, headache, muscle aches or myalgias, nausea or vomiting, rash, and seizures). The rate among adults who received a primary series, but no booster or additional dose (133.5), was three times the rate among adults who received a booster or additional dose (45.0). Cohen-Stavi, C. J. et al. Vaccination offers the best way to protect against COVID-19 and its complications. Vaccinated patients during the Delta wave were 37% (over with two doses), while during the Omicron wave they were 57%. They help us to know which pages are the most and least popular and see how visitors move around the site. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. Among all adults, relative to the Delta-predominant period, COVID-19related illness was the primary reason for admission for a smaller percentage of hospitalizations (87.5% versus 95.5%, p<0.01), and median length of stay was shorter (4 versus 5 days, p<0.01) during the Omicron-predominant period; during this period, the proportion of patients admitted to an intensive care unit, who received invasive mechanical ventilation, and who died in-hospital decreased significantly (all p<0.01). Our additional supplemental analysis suggests that pregnant persons who received at least one vaccine dose before pregnancy should complete their vaccination series during pregnancy to provide protection to their children during the first 6 months of life. WHO/Europe | The Omicron variant: sorting fact from myth The state has administered 3.2 million vaccine doses since Dec. 1 alone, but lagging rates between full vaccination and first doses for adults especially (82.6% vs. 95%) are becoming a point of . . Hospitalization Risk from Omicron 'Around a Third of Delta' - WebMD J. Med. Carlsen, E. O. et al. Office of the Vice President for Research, University of Minnesota, Minneapolis, MN, 2023 Regents of the University of Minnesota. N. Engl. Several conditions, including cancer of the blood or bone marrow and dementia, were associated with HRs greater than 3. the date of publication. Data were available for researchers who meet the criteria for access to Kaiser Permanente Northern California confidential data. Vaccinations were limited only to those received during pregnancy. Cite this article. 384, 403416 (2021). Most QCovid risk groups were tied to an increased risk of post-booster death, except congenital heart disease, asthma, and previous fracture. Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. As infants aged, protection provided by maternal vaccination decreased during both periods. In-hospital death status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. In the TND, we estimated that during the Delta predominant period, maternal vaccination with at least doses reduced the infants risk of testing SARS-CoV-2 positive by 95% (95% CI:76, 99) during the first 2 months of life, 70% (95% CI: 52, 82) during the first 4 months of life, and 61% (95% CI: 42, 74) during the first 6 months of life (Supplemental Table2). Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infection. Ann Intern Med 2021;174:140919. A WHO spokesman says China informed the WHO about the case, which involves a 53-year-old woman, on Feb 24. By clicking Sign up, you agree to receive marketing emails from Insider https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb. Effect of COVID-19 Vaccination on the In-Hospital Prognosis of Patients MMWR Morb Mortal Wkly Rep 2021;70:108893. PubMedGoogle Scholar. COVID Data Tracker Weekly Review | CDC Morb. Between December 15, 2020, and May 31, 2022, we identified 62,117 infants born at Kaiser Permanente Northern California (KPNC), an integrated healthcare delivery organization. 387, 187189 (2022). Models were adjusted for the covariates listed above. Partially vaccinated adults, and those who received a single dose of a 1-dose product <14 days before the positive SARS-CoV-2 test result were not included in analyses by vaccination status but were included in rates and overall proportions that were not stratified by vaccination status. Data requests may be sent to Kaiser Permanente Division of Research: DOR.IRB.Submissions@kp.org. 4% of cases) without NHS numbers were excluded from our primary analysis. Three recent epidemiological studies found that vaccination during pregnancy was associated with a reduced risk of SARS-CoV-2 infection in infants during their first 4 months of life and a reduced risk of hospitalization during the first 5 months of life17,18,19. We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Acosta AM, Garg S, Pham H, et al. Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons. Wkly. Starting the week ending December 4, 2021, Maryland data are not included in calculations but are included in previous weeks. A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. part 56; 42 U.S.C. The objective of this study was to further evaluate the effectiveness of at least two doses of mRNA COVID-19 vaccination during pregnancy for preventing SARS-CoV-2 infection in infants during the first 2, 4, and 6 months of life during the Delta and Omicron variant periods. image, https://doi.org/10.1038/s41586-022-04474-x, https://doi.org/10.1038/s41586-022-04479-6, https://doi.org/10.1101/2022.01.18.22269082, https://www.gov.uk/government/statistics/national-flu-and-covid-19-surveillance-reports-2021-to-2022-season, Download .pdf (.95 J. Late last year, as Omicron was spreading fast in the US, hospitalization rates per 100,000 rose sharply among unvaccinated adults, while rates in those who were fully vaccinated remained low.
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